2026-07-21T15:46:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/191192024-11-29T23:59:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Cordero, Alex
author
Santamaría, Patricia G
author
González-Suárez, Eva
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Ciencia y Universidades (España)
funder
Fundacio La Marato de TV3
2024-04-04T12:07:23Z
2024-04-04T12:07:23Z
2023-02-18
J Mammary Gland Biol Neoplasia . 2023 ;28(1):2
10.1007/s10911-023-09530-4
1573-7039
Journal of mammary gland biology and neoplasia
36808257
http://hdl.handle.net/20.500.12105/19119
Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. We observed that Rank expression in PyMT+/- and Neu+/- mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. In spite of this, Rank expression eventually promotes tumor aggressiveness once tumorigenesis is established.
eng
Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.
journal article
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rankectopicexpression_2023.pdf
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10911_2023_9530_MOESM1_ESM.pdf
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rankectopicexpression_2023.pdf.txt
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