2026-06-14T13:00:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/191162024-11-29T21:21:16Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Foronda, Miguel
author
Morgado-Palacin, Lucia
author
Gómez-López, Gonzalo
author
Domínguez, Orlando
author
Pisano, David G
author
Blasco, MA
funder
Marie Curie
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Körber Foundation
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación AXA
funder
Fundación Lilly
funder
Fundación Botín
2024-04-04T11:18:30Z
2024-04-04T11:18:30Z
2015-12
Genom Data . 2015 Aug 3:6:21-4.
10.1016/j.gdata.2015.07.030
2213-5960
Genomics data
26697322
http://hdl.handle.net/20.500.12105/19116
Adult stem cells (ASCs) reside in specific niches in a quiescent state in adult mammals. Upon specific cues they become activated and respond by self-renewing and differentiating into newly generated specialised cells that ensure appropriate tissue fitness. ASC quiescence also serves as a tumour suppression mechanism by hampering cellular transformation and expansion (White AC et al., 2014). Some genes restricted to early embryonic development and adult stem cell niches are often potent modulators of stem cell quiescence, and derailed expression of these is commonly associated to cancer (Vervoort SJ et al., 2013). Among them, it has been shown that recommissioned Sox4 expression facilitates proliferation, survival and migration of malignant cells. By generating a conditional Knockout mouse model in stratified epithelia (Sox4 (cKO) mice), we demonstrated a delayed plucking-induced Anagen in the absence of Sox4. Skin global transcriptome analysis revealed a prominent defect in the induction of transcriptional networks that control hair follicle stem cell (HFSC) activation such as those regulated by Wnt/Ctnnb1, Shh, Myc or Sox9, cell cycle and DNA damage response-associated pathways. Besides, Sox4 (cKO) mice are resistant to skin carcinogenesis, thus linking Sox4 to both normal and pathological HFSC activation (Foronda M et al., 2014). Here we provide additional details on the analysis of Sox4-regulated transcriptome in Telogen and Anagen skin. The raw and processed microarray data is deposited in GEO under GSE58155.
eng
Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.
journal article
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URL
https://repisalud.isciii.es/bitstreams/05f46315-b539-4968-a9a8-fefe8a96b579/download
File
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application/pdf
profilingofsox4-dependent_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/767c89cc-8c74-4642-b95e-fed83a208820/download
File
MD5
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text/plain
profilingofsox4-dependent_2015.pdf.txt