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oai:repisalud.isciii.es:20.500.12105/191122024-11-29T14:05:03Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Bär, Christian author Blasco, MA author 2016-01-20 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging. Here, we discuss the role of telomere shortening as a direct cause for aging and age-related diseases. In particular, we draw attention to the fact that telomere length influences longevity. Furthermore, we discuss intrinsic and environmental factors that can impact on human telomere erosion. Finally, we highlight recent advances in telomerase-based therapeutic strategies for the treatment of diseases associated with extremely short telomeres owing to mutations in telomerase, as well as age-related diseases, and ultimately aging itself. F1000Res . 2016 Jan 20:5 10.12688/f1000research.7020.1 2046-1402 F1000Research 27081482 http://hdl.handle.net/20.500.12105/19112 Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases.