2026-08-05T15:43:01Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/190972025-04-07T18:32:31Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961col_20.500.12105_16978col_20.500.12105_16987
Repisalud author Bassetti, Matteo author Giacobbe, Daniele R author Agvald-Ohman, Christina author Akova, Murat author Alastruey-Izquierdo, Ana author Arikan-Akdagli, Sevtap author Azoulay, Elie author Blot, Stijn author Cornely, Oliver A author Cuenca-Estrella, Manuel author de Lange, Dylan W author De Rosa, Francesco G author De Waele, Jan J author Dimopoulos, George author Garnacho-Montero, José author Hoenigl, Martin author Kanj, Souha S author Koehler, Philipp author Kullberg, Bart J author Lamoth, Frédéric author Lass-Flörl, Cornelia author Maertens, Johan author Martin-Loeches, Ignacio author Muñoz, Patricia author Poulakou, Garyphallia author Rello, Jordi author Sanguinetti, Maurizio author Taccone, Fabio S author Timsit, Jean-François author Torres, Antoni author Vazquez, Jose A author Wauters, Joost author Asperges, Erika author Cortegiani, Andrea author Grecchi, Cecilia author Karaiskos, Ilias author Le Bihan, Clément author Mercier, Toine author Mortensen, Klaus L author Peghin, Maddalena author Rebuffi, Chiara author Tejada, Sofia author Vena, Antonio author Zuccaro, Valentina author Scudeller, Luigia author Calandra, Thierry author Study Group for Infections in Critically Ill Patients of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP) author Fungal Infection Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG) author European Society of Intensive Care Medicine (ESICM) author European Confederation of Medical Mycology (ECMM) author Mycoses Study Group Education and Research Consortium (MSGERC) author International Society of Antimicrobial Chemotherapy (ISAC) author International Society for Human and Animal Mycology (ISHAM) author Austrian Society for Medical Mycology (ÖGMM) author Italian Society of Anesthesia, Analgesia, Reanimation, and Intensive Care (SIAARTI) author Italian Society of Anti-Infective Therapy (SITA) author FUNDICU Collaborators funder Research Foundation - Flanders funder European Society of Clinical Microbiology and Infectious Diseases 2024-04-01T11:17:19Z 2024-04-01T11:17:19Z 2024-03-21 Intensive Care Med. 2024 Apr;50(4):502-515. 10.1007/s00134-024-07341-7 1432-1238 Intensive care medicine 38512399 http://hdl.handle.net/20.500.12105/19097 Purpose: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs). Methods: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method. Results: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies. eng Invasive fungal diseases Aspergillus Candida Consensus Definitions Diagnosis Intensive care unit Research Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM research article 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 URL https://repisalud.isciii.es/bitstreams/e4c38759-be72-4f93-88d8-ec3fd630fd87/download File MD5 e1e36ad9529aea6c4c3c700997dcd790 2077580 application/pdf InvasiveFungalDiseasesAdultPatients_2024.pdf URL https://repisalud.isciii.es/bitstreams/7150da67-e640-4185-bbb6-c5e9e3bb00fe/download File MD5 0f235bf974e147e6cc1342c0539ea4aa 116860 application/pdf Supplementary_InvasiveFungalDiseasesAdultPatients_2024.pdf URL https://repisalud.isciii.es/bitstreams/491e07d3-3ec3-4fd4-a708-164d3b2967e9/download File MD5 dee24e7fb08add211a08c0a957516c91 85553 text/plain InvasiveFungalDiseasesAdultPatients_2024.pdf.txt URL https://repisalud.isciii.es/bitstreams/4bbb101f-97a7-4cee-b451-06235b9a436f/download File MD5 cfabe8272a5a7d140d53ceee47221361 6928 text/plain Supplementary_InvasiveFungalDiseasesAdultPatients_2024.pdf.txt