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00925njm 22002777a 4500 dc Bassetti, Matteo author Giacobbe, Daniele R author Agvald-Ohman, Christina author Akova, Murat author Alastruey-Izquierdo, Ana author Arikan-Akdagli, Sevtap author Azoulay, Elie author Blot, Stijn author Cornely, Oliver A author Cuenca-Estrella, Manuel author de Lange, Dylan W author De Rosa, Francesco G author De Waele, Jan J author Dimopoulos, George author Garnacho-Montero, José author Hoenigl, Martin author Kanj, Souha S author Koehler, Philipp author Kullberg, Bart J author Lamoth, Frédéric author Lass-Flörl, Cornelia author Maertens, Johan author Martin-Loeches, Ignacio author Muñoz, Patricia author Poulakou, Garyphallia author Rello, Jordi author Sanguinetti, Maurizio author Taccone, Fabio S author Timsit, Jean-François author Torres, Antoni author Vazquez, Jose A author Wauters, Joost author Asperges, Erika author Cortegiani, Andrea author Grecchi, Cecilia author Karaiskos, Ilias author Le Bihan, Clément author Mercier, Toine author Mortensen, Klaus L author Peghin, Maddalena author Rebuffi, Chiara author Tejada, Sofia author Vena, Antonio author Zuccaro, Valentina author Scudeller, Luigia author Calandra, Thierry author Study Group for Infections in Critically Ill Patients of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP) author Fungal Infection Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG) author European Society of Intensive Care Medicine (ESICM) author European Confederation of Medical Mycology (ECMM) author Mycoses Study Group Education and Research Consortium (MSGERC) author International Society of Antimicrobial Chemotherapy (ISAC) author International Society for Human and Animal Mycology (ISHAM) author Austrian Society for Medical Mycology (ÖGMM) author Italian Society of Anesthesia, Analgesia, Reanimation, and Intensive Care (SIAARTI) author Italian Society of Anti-Infective Therapy (SITA) author FUNDICU Collaborators author 2024-03-21 Purpose: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs). Methods: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method. Results: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies. Intensive Care Med. 2024 Apr;50(4):502-515. 10.1007/s00134-024-07341-7 1432-1238 Intensive care medicine 38512399 http://hdl.handle.net/20.500.12105/19097 Invasive fungal diseases Aspergillus Candida Consensus Definitions Diagnosis Intensive care unit Research Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM