2026-05-31T17:09:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/190942025-05-05T11:08:10Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16958col_20.500.12105_16959col_20.500.12105_16960col_20.500.12105_16962col_20.500.12105_16963col_20.500.12105_16964col_20.500.12105_16966col_20.500.12105_16967col_20.500.12105_16969col_20.500.12105_16970col_20.500.12105_16971col_20.500.12105_16973col_20.500.12105_16976col_20.500.12105_16975col_20.500.12105_16977col_20.500.12105_16978col_20.500.12105_16981col_20.500.12105_16983col_20.500.12105_16972col_20.500.12105_16988col_20.500.12105_19618
Repisalud
author
Pérez-Jurado, Luis Alberto
author
Cáceres, Alejandro
author
Balagué-Dobón, Laura
author
Esko, Tonu
author
López de Heredia, Miguel
author
Quintela, Inés
author
Cruz, Raquel
author
Lapunzina, Pablo
author
Carracedo, Ángel
author
SCOURGE Cohort Group
author
González, Juan R
author
Meijome, Xose M
author
Brochado-Kith, Oscar
author
Ceballos, Francisco C
author
Fernandez-Rodriguez, Amanda
author
Jimenez-Sousa, Maria Angeles
author
Martin-Vicente, Maria
author
Resino, Salvador
author
Virseda-Berdices, Ana
funder
Government of Catalonia (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Banco Santander
funder
Estonian Research Council
funder
Amancio Ortega Foundation
2024-04-01T07:57:20Z
2024-04-01T07:57:20Z
2024-02-19
Commun Biol. 2024 Feb 19;7(1):202.
10.1038/s42003-024-05805-6
2399-3642
Communications biology
38374351
http://hdl.handle.net/20.500.12105/19094
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.
eng
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
research article
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