2026-06-14T03:28:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/190652024-09-28T00:09:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud
author
Martin-Folgar, Raquel
author
González-Caballero, MCarmen
author
Torres-Ruiz, Mónica
author
Cañas Portilla, Ana Isabel
author
De Alba-González, Mercedes
author
Liste-Noya, Isabel
author
Morales, Mónica
2024-03-22T12:43:14Z
2024-03-22T12:43:14Z
2024
PLoS One. 2024 Jan 3;19(1):e0295816.
10.1371/journal.pone.0295816
1932-6203
PloS one
38170698
http://hdl.handle.net/20.500.12105/19065
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
eng
Molecular effects of polystyrene nanoplastics on human neural stem cells
research article
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URL
https://repisalud.isciii.es/bitstreams/158d176f-d882-4886-8c47-5aa8da2dd11d/download
File
MD5
f90346132d301d0bc76396cd187668a3
1594280
application/pdf
MolecularEffectsPolystyreneNanoplastics_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/43fba1ca-3a77-4845-8f56-faf9adbe6638/download
File
MD5
d3f76a85258ef40f25898486bb107e1f
67757
text/plain
MolecularEffectsPolystyreneNanoplastics_2024.pdf.txt