2026-06-14T06:44:34Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/190652024-09-28T00:09:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Martin-Folgar, Raquel author González-Caballero, MCarmen author Torres-Ruiz, Mónica author Cañas Portilla, Ana Isabel author De Alba-González, Mercedes author Liste-Noya, Isabel author Morales, Mónica author 2024 Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases. PLoS One. 2024 Jan 3;19(1):e0295816. 10.1371/journal.pone.0295816 1932-6203 PloS one 38170698 http://hdl.handle.net/20.500.12105/19065 Molecular effects of polystyrene nanoplastics on human neural stem cells