2026-04-29T12:23:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/190142025-05-05T10:16:04Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Rodríguez-Muñoz, María F author Martín-Martín, Clara author Kovacheva, Katina author Olivares, Maria Eugenia author Izquierdo, Nuria author Perez-Romero, Pilar author Garcia-Rios, Estefani author 2024-02-29 Background: Human Cytomegalovirus (HCMV) is the most frequent congenital infection worldwide causing important sequelae. However, no vaccine or antiviral treatments are currently available, thus interventions are restricted to behavioral measures. The aim of this systematic review was to assess evidence from available intervention studies using hygiene-based measures to prevent HCMV infection during pregnancy. Methods: Studies published from 1972 to 2023 were searched in Medline, PsycInfo, and Clinical Trials (PROSPERO, CRD42022344840) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality was assessed by two authors, using ROBE-2 and MINORS. Results: After reviewing 6 selected articles, the outcome analysis suggested that implementation of hygiene-based interventions during pregnancy prevent, to some extent, the acquisition of congenital HCMV. Conclusions: However, these conclusions are based on limited and low-quality evidence available from few studies using this type of intervention in clinical practice. Thus, it would be necessary to perform effective and homogeneous intervention studies using hygiene-based measures, evaluated in high-quality randomized controlled trials (RCTs). BMC Pregnancy Childbirth. 2024 Feb 29;24(1):172. 10.1186/s12884-024-06367-5 1471-2393 BMC pregnancy and childbirth 38424481 http://hdl.handle.net/20.500.12105/19014 Systematic review Cytomegalovirus Pregnancy Counselling Seroconversion Hygiene-based measures for the prevention of cytomegalovirus infection in pregnant women: a systematic review