2026-06-14T03:31:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/190102025-04-23T08:12:42Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
López-Herrero, R
author
Sánchez-de Prada, L
author
Tamayo-Velasco, A
author
Heredia-Rodríguez, María
author
Bardají Carrillo, M
author
Jorge Monjas, P
author
de la Varga-Martínez, O
author
Resino, Salvador
author
Sarmentero-López de Quintana, G
author
Gómez-Sánchez, E
author
Tamayo, E
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Junta de Castilla y León (España)
funder
Fundación Ramón Areces
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2024-03-20T08:20:31Z
2024-03-20T08:20:31Z
2024-03-03
Sci Rep. 2024 Mar 3;14(1):5203.
10.1038/s41598-024-54340-1
2045-2322
Scientific reports
38433130
http://hdl.handle.net/20.500.12105/19010
We realize a nationwide population-based retrospective study to analyze the characteristics and risk factors of fungal co-infections in COVID-19 hospitalized patients as well as describe their causative agents in the Spanish population in 2020 and 2021. Data were obtained from records in the Minimum Basic Data Set of the National Surveillance System for Hospital Data in Spain, provided by the Ministry of Health, and annually published with two years lag. The assessment of the risk associated with the development of healthcare-associated fungal co-infections was assessed using an adjusted logistic regression model. The incidence of fungal co-infection in COVID-19 hospitalized patients was 1.41%. The main risk factors associated were surgery, sepsis, age, male gender, obesity, and COPD. Co-infection was associated with worse outcomes including higher in-hospital and in ICU mortality, and higher length of stay. Candida spp. and Aspergillus spp. were the microorganisms more frequent. This is the first study analyzing fungal coinfection at a national level in hospitalized patients with COVID-19 in Spanish population and one of the few studies available that demonstrate that surgery was an independent risk factor of Aspergillosis coinfection in COVID-19 patients.
eng
COVID-19
Fungal infection
Spain
Hospitalization
Epidemiology of fungal infection in COVID 19 in Spain during 2020 and 2021: a nationwide study
research article
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