2026-04-29T06:16:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189932025-02-04T12:44:28Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Carrero, Laura
author
Antequera, Desireé
author
Municio, Cristina
author
Carro, Eva
2024-03-18T14:36:16Z
2024-03-18T14:36:16Z
2024
Neural Regen Res. 2024;19(9):1967-1972.
1673-5374
http://hdl.handle.net/20.500.12105/18993
38227523
10.4103/1673-5374.390962
Neural regeneration research
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.
eng
Alzheimer’s disease
Amyloid
Circadian rhythm
Neurodegeneration
Retina
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
research article
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URL
https://repisalud.isciii.es/bitstreams/7dbd0478-cbbb-4402-883e-51952226a41e/download
File
MD5
701a6d4b199aaf7ba3a53d7379cbb685
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application/pdf
CircadianRhythmDisruptionRetinalDysfunction_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/39a4ca6d-194d-4dc9-a9d4-e4e28dafc27d/download
File
MD5
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text/plain
CircadianRhythmDisruptionRetinalDysfunction_2024.pdf.txt