2026-04-29T06:15:57Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/189932025-02-04T12:44:28Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617

00925njm 22002777a 4500 dc Carrero, Laura author Antequera, Desireé author Municio, Cristina author Carro, Eva author 2024 Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm. Neural Regen Res. 2024;19(9):1967-1972. 1673-5374 http://hdl.handle.net/20.500.12105/18993 38227523 10.4103/1673-5374.390962 Neural regeneration research Alzheimer’s disease Amyloid Circadian rhythm Neurodegeneration Retina Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?