2026-08-29T12:39:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/189842024-09-27T16:41:36Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Magalhães, Andreia D author Amstutz, Deborah author Petermann, Katrin author Debove, Ines author Sousa, Mário author Maradan-Gachet, Marie E author Lachenmayer, Martin Lenard author Waskönig, Julia author Murcia-Carretero, Sandra author Diamantaras, Andreas Antonios author Tinkhauser, Gerd author Nowacki, Andreas author Pollo, Claudio author Rodriguez-Blazquez, Carmen author Martinez-Martin, Pablo author Krack, Paul author 2024 Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson's disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study was to evaluate the effects of STN-DBS on neuropsychiatric symptoms in PD. Methods: We retrospectively assessed 26 patients with PD who underwent a preoperative levodopa challenge and postoperative levodopa and stimulation challenges 1 year after STN-DBS. Based on the Neuropsychiatric Fluctuations Scale, Neuropsychiatric State Scores and Neuropsychiatric Fluctuation Indices (NFIs) were calculated. Mixed-effects models with random effects for intercept were used to examine the association of Neuropsychiatric State Score and NFI with the different assessment conditions. Results: In acute challenge conditions, there was an estimated increase of 15.9 points in the Neuropsychiatric State Score in stimulation ON conditions (95% CI 11.4 to 20.6, p<0.001) and 7.6 points in medication ON conditions (95% CI 3.3 to 11.9, p<0.001). Neuropsychiatric fluctuations induced by levodopa, quantified with NFI, decreased by 35.54% (95% CI 49.3 to 21.8, p<0.001) 1 year after STN-DBS. Conclusions: Bilateral STN-DBS at therapeutic parameters has acute psychotropic effects similar to levodopa and can modulate and decrease levodopa-induced neuropsychiatric fluctuations. BMJ Neurol Open. 2024 Jan 6;6(1):e000524. 10.1136/bmjno-2023-000524 2632-6140 BMJ neurology open 38196982 http://hdl.handle.net/20.500.12105/18984 Electrical stimulation Neuropsychiatry Parkinson's disease Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson's disease