2026-05-06T00:58:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189792024-11-29T13:28:32Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
López-Otín, Carlos
author
Blasco, MA
author
Partridge, Linda
author
Serrano, Manuel
author
Kroemer, Guido
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación La Caixa
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Max Planck Society
funder
UK Research and Innovation
funder
Agence Nationale de la Recherche (Francia)
funder
Government of Catalonia (España)
funder
Fondation ARC pour la recherche sur le cancer
funder
Fundación Bancaria Caja de Ahorros de Asturias
funder
IdEx Universitede Paris
funder
SIRIC Cancer Research and Personalized Medicine (CARPEM)
funder
SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
funder
Seerave Foundation
2024-03-18T11:08:07Z
2024-03-18T11:08:07Z
2023-01-19
Cell . 2023 ;186(2):243-278.
10.1016/j.cell.2022.11.001
1097-4172
Cell
36599349
http://hdl.handle.net/20.500.12105/18979
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
eng
Hallmarks of aging: An expanding universe.
journal article
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URL
https://repisalud.isciii.es/bitstreams/50b2dc3b-2261-4c14-89ce-3e155584985d/download
File
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application/pdf
hallmarksofaging-2023.pdf
URL
https://repisalud.isciii.es/bitstreams/780dba48-787c-4150-96f7-027f4aebe5ad/download
File
MD5
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text/plain
hallmarksofaging-2023.pdf.txt