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oai:repisalud.isciii.es:20.500.12105/189792024-11-29T13:28:32Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc López-Otín, Carlos author Blasco, MA author Partridge, Linda author Serrano, Manuel author Kroemer, Guido author 2023-01-19 Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress. Cell . 2023 ;186(2):243-278. 10.1016/j.cell.2022.11.001 1097-4172 Cell 36599349 http://hdl.handle.net/20.500.12105/18979 Hallmarks of aging: An expanding universe.