2026-06-14T03:31:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189682025-03-27T10:27:11Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16964
Repisalud
author
García-García, María Luz
author
Alcolea, Sonia
author
Alonso-López, Patricia
author
Martín-Martín, Clara
author
Tena-García, Guadalupe
author
Casas Flecha, Inmaculada
author
Pozo Sanchez, Francisco
author
Méndez-Echevarría, Ana
author
Hurtado-Gallego, Jara
author
Calvo, Cristina
funder
Instituto de Salud Carlos III
2024-03-15T13:55:41Z
2024-03-15T13:55:41Z
2023-11-28
Pathogens. 2023 Nov 28;12(12):1397.
10.3390/pathogens12121397
2076-0817
Pathogens (Basel, Switzerland)
38133281
http://hdl.handle.net/20.500.12105/18968
Bronchiolitis is a viral respiratory infection, with respiratory syncytial virus (RSV) being the most frequent agent, requiring hospitalization in 1% of affected children. However, there continues to be a noteworthy incidence of antibiotic prescription in this setting, further exacerbating the global issue of antibiotic resistance. This study, conducted at Severo Ochoa Hospital in Madrid, Spain, focused on antibiotic usage in children under 2 years of age who were hospitalized for bronchiolitis between 2004 and 2022. In that time, 5438 children were admitted with acute respiratory infection, and 1715 infants (31.5%) with acute bronchiolitis were included. In total, 1470 (87%) had a positive viral identification (66% RSV, 32% HRV). Initially, antibiotics were prescribed to 13.4% of infants, but this percentage decreased to 7% during the COVID-19 pandemic thanks to adherence to guidelines and the implementation of rapid and precise viral diagnostic methods in the hospital. HBoV- and HAdV-infected children and those with viral coinfections were more likely to receive antibiotics in the univariate analysis. A multivariate logistic regression analysis revealed a statistically independent association between antibiotic prescription and fever > 38 °C (p < 0.001), abnormal chest-X ray (p < 0.001), ICU admission (p = 0.015), and serum CRP (p < 0.001). In conclusion, following guidelines and the availability of rapid and reliable viral diagnostic methods dramatically reduces the unnecessary use of antibiotics in infants with severe bronchiolitis.
eng
Antibiotics
Bronchiolitis
Respiratory virus
Respiratory syncytial virus
Human bocavirus
Human adenovirus
Rhinovirus
Chest X-ray
Antibiotic Utilization in Hospitalized Children with Bronchiolitis: A Prospective Study Investigating Clinical and Epidemiological Characteristics at a Secondary Hospital in Madrid (2004-2022)
research article
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AntibioticUtilizationHospitalizedChildrenBronchiolitis_2023.pdf
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AntibioticUtilizationHospitalizedChildrenBronchiolitis_2023.pdf.txt