2026-05-17T00:18:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189662024-11-29T14:21:42Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Sanz-Ros, Jorge
author
Romero-García, Nekane
author
Mas-Bargues, Cristina
author
Monleón, Daniel
author
Gordevicius, Juozas
author
Brooke, Robert T
author
Dromant, Mar
author
Díaz, Ana
author
Derevyanko, Aksinya
author
Guío-Carrión, Ana
author
Román-Domínguez, Aurora
author
Inglés, Marta
author
Blasco, MA
author
Horvath, Steve
author
Viña, Jose
author
Borrás, Consuelo
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Generalitat Valenciana (España)
funder
Fundación Ramón Areces
funder
Center for Forestry Research & Experimentation (CIEF)
2024-03-15T11:20:09Z
2024-03-15T11:20:09Z
2022-10-21
Sci Adv . 2022;8(42):eabq2226.
10.1126/sciadv.abq2226
2375-2548
Science advances
36260670
http://hdl.handle.net/20.500.12105/18966
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement in several parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function, as well as an important decrease in frailty. ADSC-sEVs induced proregenerative effects and a decrease in oxidative stress, inflammation, and senescence markers in muscle and kidney. Moreover, predicted epigenetic age was lower in tissues of old mice treated with ADSC-sEVs and their metabolome changed to a youth-like pattern. Last, we gained some insight into the microRNAs contained in sEVs that might be responsible for the observed effects. We propose that young sEV treatment can promote healthy aging.
eng
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
journal article
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URL
https://repisalud.isciii.es/bitstreams/316f132d-8f3c-49c6-b7c3-7da0c5336576/download
File
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application/pdf
Smallextracellularvesiclesfromyoung_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/c6afdade-ee8f-4eaf-9db4-c99f02a8a13a/download
File
MD5
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text/plain
Smallextracellularvesiclesfromyoung_2022.pdf.txt