2026-05-17T00:18:25Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/189662024-11-29T14:21:42Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Sanz-Ros, Jorge author Romero-García, Nekane author Mas-Bargues, Cristina author Monleón, Daniel author Gordevicius, Juozas author Brooke, Robert T author Dromant, Mar author Díaz, Ana author Derevyanko, Aksinya author Guío-Carrión, Ana author Román-Domínguez, Aurora author Inglés, Marta author Blasco, MA author Horvath, Steve author Viña, Jose author Borrás, Consuelo author 2022-10-21 Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement in several parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function, as well as an important decrease in frailty. ADSC-sEVs induced proregenerative effects and a decrease in oxidative stress, inflammation, and senescence markers in muscle and kidney. Moreover, predicted epigenetic age was lower in tissues of old mice treated with ADSC-sEVs and their metabolome changed to a youth-like pattern. Last, we gained some insight into the microRNAs contained in sEVs that might be responsible for the observed effects. We propose that young sEV treatment can promote healthy aging. Sci Adv . 2022;8(42):eabq2226. 10.1126/sciadv.abq2226 2375-2548 Science advances 36260670 http://hdl.handle.net/20.500.12105/18966 Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.