2026-04-29T06:15:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189312024-11-29T14:04:02Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Zheng, Di
author
Pisano, Filippo
author
Collard, Liam
author
Balena, Antonio
author
Pisanello, Marco
author
Spagnolo, Barbara
author
Mach-Batlle, Rosa
author
Tantussi, Francesco
author
Carbone, Luigi
author
De Angelis, Francesco
author
Valiente, Manuel
author
de la Prida, Liset M
author
Ciracì, Cristian
author
De Vittorio, Massimo
author
Pisanello, Ferruccio
funder
European Union (EU)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
United States Department of Health and Human Services
2024-03-13T12:53:57Z
2024-03-13T12:53:57Z
2023-03
Adv Mater . 2023 ;35(11):e2200902
http://hdl.handle.net/20.500.12105/18931
36479741
10.1002/adma.202200902
1521-4095
Advanced materials (Deerfield Beach, Fla.)
Integration of plasmonic nanostructures with fiber-optics-based neural probes enables label-free detection of molecular fingerprints via surface-enhanced Raman spectroscopy (SERS), and it represents a fascinating technological horizon to investigate brain function. However, developing neuroplasmonic probes that can interface with deep brain regions with minimal invasiveness while providing the sensitivity to detect biomolecular signatures in a physiological environment is challenging, in particular because the same waveguide must be employed for both delivering excitation light and collecting the resulting scattered photons. Here, a SERS-active neural probe based on a tapered optical fiber (TF) decorated with gold nanoislands (NIs) that can detect neurotransmitters down to the micromolar range is presented. To do this, a novel, nonplanar repeated dewetting technique to fabricate gold NIs with sub-10 nm gaps, uniformly distributed on the wide (square millimeter scale in surface area), highly curved surface of TF is developed. It is experimentally and numerically shown that the amplified broadband near-field enhancement of the high-density NIs layer allows for achieving a limit of detection in aqueous solution of 10-7 m for rhodamine 6G and 10-5 m for serotonin and dopamine through SERS at near-infrared wavelengths. The NIs-TF technology is envisioned as a first step toward the unexplored frontier of in vivo label-free plasmonic neural interfaces.
eng
Toward Plasmonic Neural Probes: SERS Detection of Neurotransmitters through Gold-Nanoislands-Decorated Tapered Optical Fibers with Sub-10 nm Gaps.
journal article
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