2026-04-29T12:23:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/189262024-11-29T21:10:39Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Roncador, Giovanna
author
Puñet-Ortiz, Joan
author
Maestre, Maestre L
author
Rodríguez-Lobato, Luis Gerardo
author
Jiménez, Scherezade
author
Mena, Mari-Pau
author
Reyes-García, Ana Isabel
author
García-González, Álvaro
author
García, Juan F
author
Piris, Miguel Ángel
author
Montes-Moreno, Santiago
author
Rodríguez-Justo, Manuel
author
Fernández de Larrea, Carlos
author
Engel, Pablo
funder
Instituto de Salud Carlos III
funder
Asociación Española Contra el Cáncer
funder
Fundación La Caixa
funder
European Union (EU)
funder
Marie Curie Actions
2024-03-13T12:28:32Z
2024-03-13T12:28:32Z
2022-04-26
Cancers (Basel) . 2022 ;14(9):2154
10.3390/cancers14092154
2072-6694
Cancers
35565280
http://hdl.handle.net/20.500.12105/18926
CD229 (Ly9) homophilic receptor, which belongs to the SLAM family of cell-surface molecules, is predominantly expressed on B and T cells. It acts as a signaling molecule, regulating lymphocyte homoeostasis and activation. Studies of CD229 function indicate that this receptor functions as a regulator of the development of marginal-zone B cells and other innate-like T and B lymphocytes. The expression on leukemias and lymphomas remains poorly understood due to the lack of CD229 monoclonal antibodies (mAb) for immunohistochemistry application (IHC). In this study, we used a new mAb against the cytoplasmic region of CD229 to study the expression of CD229 on normal tissues and B-cell malignancies, including multiple myeloma (MM), using tissue microarrays. We showed CD229 to be restricted to hematopoietic cells. It was strongly expressed in all cases of MM and in most marginal-zone lymphomas (MZL). Moderate CD229 expression was also found in chronic lymphocyte leukemia (CLL), follicular (FL), classic mantle-cell (MCL) and diffuse large B-cell lymphoma. Given the high expression on myeloma cells, we also analyzed for the presence of soluble CD229 in the sera of these patients. Serum levels of soluble CD229 (sCD229) at the time of diagnosis in MM patients could be useful as a prognostic biomarker. In conclusion, our results indicate that CD229 represents not only a useful biomarker but also an attractive therapeutic target.
eng
CD229 (Ly9) a Novel Biomarker for B-Cell Malignancies and Multiple Myeloma.
journal article
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URL
https://repisalud.isciii.es/bitstreams/f25b2c6e-2e87-4a30-a164-17d96c6433a6/download
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CD229(Ly9)aNovelBiomarker_2022.pdf
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https://repisalud.isciii.es/bitstreams/81f6b858-7b3d-4c46-b7f5-e81222761b9d/download
File
MD5
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65574
text/plain
CD229(Ly9)aNovelBiomarker_2022.pdf.txt