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oai:repisalud.isciii.es:20.500.12105/188842024-11-28T15:11:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Galeano, Pablo author Blanco, Eduardo author Logica Tornatore, Tamara M A author Romero, Juan I author Holubiec, Mariana I author Rodríguez de Fonseca, Fernando author Capani, Francisco author 2015-01-05 Continuous environmental stimulation induced by exposure to enriched environment (EE) has yielded cognitive benefits in different models of brain injury. Perinatal asphyxia results from a lack of oxygen supply to the fetus and is associated with long-lasting neurological deficits. However, the effects of EE in middle-aged rats suffering perinatal asphyxia are unknown. Therefore, the aim of the present study was to assess whether life-long exposure to EE could counteract the cognitive and behavioral alterations in middle-aged asphyctic rats. Experimental groups consisted of rats born vaginally (CTL), by cesarean section (C+), or by C+ following 19 min of asphyxia at birth (PA). At weaning, rats were assigned to standard (SE) or enriched environment (EE) for 18 months. During the last month of housing, animals were submitted to a behavioral test battery including Elevated Plus Maze, Open Field, Novel Object Recognition and Morris water maze (MWM). Results showed that middle-aged asphyctic rats, reared in SE, exhibited an impaired performance in the spatial reference and working memory versions of the MWM. EE was able to counteract these cognitive impairments. Moreover, EE improved the spatial learning performance of middle-aged CTL and C+ rats. On the other hand, all groups reared in SE did not differ in locomotor activity and anxiety levels, while EE reduced locomotion and anxiety, regardless of birth condition. Recognition memory was altered neither by birth condition nor by housing environment. These results support the importance of environmental stimulation across the lifespan to prevent cognitive deficits induced by perinatal asphyxia. 10.3389/fnbeh.2014.00406 1662-5153 Frontiers in Behavioral Neuroscience http://hdl.handle.net/10668/2341 25601829 http://hdl.handle.net/20.500.12105/18884 Perinatal asphyxia Environmental enrichment Aging Habituation Anxiaty Recognition memory Spatial reference memory Spatial working memory Ansiedad, Asfixia Escala de evaluación de la conducta Traumatismos cerebrales Cesárea Cognición Trastornos cognitivos Ambiente Feto Viviendas Locomoción Memoria a corto plazo Oxígeno Parto Embarazo Ratas Aprendizaje espacial Destete Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia