2026-07-22T08:14:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/188772024-11-28T14:43:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16938col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16963col_20.500.12105_16966
Repisalud
author
M�rquez, Ana
author
Ferreiro-Iglesias, Aida
author
D�vila-Fajardo, Cristina L
author
Montes, Ariana
author
Pascual-Salcedo, Dora
author
Perez-Pampin, Eva
author
Moreno-Ramos, Manuel J
author
Garc�a-Portales, Rosa
author
Navarro, Federico
author
Moreira, Virginia
author
Magro, C�sar
author
Caliz, Rafael
author
Ferrer, Miguel Angel
author
Alegre-Sancho, Juan Jos�
author
Joven, Beatriz
author
Carreira, Patricia
author
Balsa, Alejandro
author
Vasilopoulos, Yiannis
author
Sarafidou, Theologia
author
Cabeza-Barrera, Jos�
author
Narvaez, Javier
author
Raya, Enrique
author
Ca�ete, Juan D
author
Fern�ndez-Nebro, Antonio
author
Ord��ez, Mar�a del Carmen
author
de la Serna, Arturo R
author
Magallares, Berta
author
Gomez-Reino, Juan J
author
Gonz�lez, Antonio
author
Mart�n, Javier
authoraffiliation
[M�rquez,A; D�vila-Fajardo,CL; Mart�n,J] Instituto de Parasitolog�a y Biomedicina L�pez-Neyra, Consejo Superior de Investigaciones Cient�ficas (CSIC), Armilla, Granada, Spain. [Ferreiro-Iglesias,A; Montes,A; Perez-Pampin,E; Gomez-Reino,JJ; Gonz�lez,A] Laboratorio Investigaci�n 10 and Rheumatology Unit, Instituto de Investigaci�n Sanitaria-Hospital Cl�nico Universitario de Santiago, Santiago de Compostela, Spain. [D�vila-Fajardo,CL; Cabeza-Barrera,J] Department of Clinical Pharmacy, Hospital Universitario San Cecilio, Instituto de Investigaci�n Biosanitaria de Granada (IBIG), Granada, Spain. [Pascual-Salcedo,D] Department of Immunology, Instituto de Investigaci�n Sanitaria del Hospital Universitario La Paz (IdiPAZ),Research Network in Inflammation and Rheumatic Diseases (RIER), Hospital La Paz, Madrid, Spain. [Moreno-Ramos,MJ] Department of Rheumatology, Hospital Virgen de la Arrixaca,El Palmar Murcia, Spain. [Garc�a-Portales,R] Department of Rheumatology, Hospital Virgen de la Victoria, Campus de Teatinos M�laga, Spain. [Navarro,F; Moreira,V] Rheumatology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Magro,C] Department of Rheumatology, Hospital Cl�nico San Cecilio, Granada, Spain. [Caliz,R; Ferrer,MA] Rheumatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Alegre-Sancho,JJ] Department of Rheumatology, Hospital Doctor Peset, Valencia, Spain. [Joven,B; Carreira,P] Department of Rheumatology, Instituto de Investigaci�n I+12, Research Network in Inflammation and Rheumatic Diseases (RIER), Hospital Universitario 12 de Octubre, Madrid, Spain. [Balsa,A] Department of Rheumatology, Instituto de Investigaci�n Sanitaria del Hospital Universitario La Paz (IdiPAZ), Research Network in Inflammation and Rheumatic Diseases (RIER), Madrid, Spain. [Vasilopoulos,Y; Sarafidou,T] Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece. [Narvaez,J] Rheumatology Department, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. [Ca�ete,JD] Rheumatology Department, Hospital Clinic and Institut d�Investigacions Biom�diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. [Fern�ndez-Nebro,A; Ord��ez,MC] Unidad de Gesti�n Cl�nica (UGC) Rheumatology, Hospital Regional Universitario de M�laga, Instituto de Investigaci�n Biom�dica de M�laga (IBIMA), M�laga, Spain. [de la Serna,AR; Magallares,B] Rheumatology Unit, Hospital Santa Creu e San Pau, Barcelona, Spain. [Gomez-Reino,JJ] Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
2024-03-05T07:38:56Z
2024-03-05T07:38:56Z
2014-03-11
10.1186/ar4504
1478-6362
1478-6354
Arthritis research & therapy
http://hdl.handle.net/10668/2316
24612463
http://hdl.handle.net/20.500.12105/18877
Introduction: In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). The authors of that study reported that the four genetic variants were significantly associated. However, none of the associations reached GWAS significance, and two subsequent studies failed to replicate these associations. Methods: The four polymorphisms (rs12081765, rs1532269, rs17301249 and rs7305646) were genotyped in a total of 634 TNFi-treated RA patients of Spanish Caucasian origin. Four outcomes were evaluated: changes in the Disease Activity Score in 28 joints (DAS28) after 6 and 12 months of treatment and classification according to the European League Against Rheumatism (EULAR) response criteria at the same time points. Association with DAS28 changes was assessed by linear regression using an additive genetic model. Contingency tables of genotype and allele frequencies between EULAR responder and nonresponder patients were compared. In addition, we combined our data with those of previously reported studies in a meta-analysis including 2,998 RA patients. Results: None of the four genetic variants showed an association with response to TNFi in any of the four outcomes analyzed in our Spanish patients. In addition, only rs1532269 yielded a suggestive association (P = 0.0033) with the response to TNFi when available data from previous studies were combined in the meta-analysis. Conclusion: Our data suggest that the rs12081765, rs1532269, rs17301249 and rs7305646 genetic variants do not have a role as genetic predictors of TNFi treatment outcomes.
eng
Antirreum�ticos
Artritis reumatoide
Estudio de asociaci�n del genoma completo
Genotipo
Polimorfismo de nucle�tido simple
Resultado del tratamiento
Factor de necrosis tumoral alfa
Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis
research article