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oai:repisalud.isciii.es:20.500.12105/188512024-10-03T13:11:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16983

00925njm 22002777a 4500 dc Gutiérrez-Bedmar, Mario author Gil, Fernando author Olmedo, Pablo author Ruiz-Canela, Miguel author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Babio, Nancy author Fitó, Montserrat author Del Val García, Jose Luís author Corella, Dolores author Sorlí, José V author Ros, Emilio author Fiol, Miquel author Estruch, Ramón author Santos-Lozano, José Manuel author Arós, Fernando author Serra-Majem, Lluís author Pintó, Xavier author Gómez-Gracia, Enrique author Muñoz-Bravo, Carlos author 2022-11-10 Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003−2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 μg/L vs. 103.8 μg/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose−response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27−0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence. Gutiérrez-Bedmar, M., Gil, F., Olmedo, P., Ruiz-Canela, M., Martínez-González, M.Á, Salas-Salvadó, J., Babio, N., Fitó, M., del Val García, J. L., Corella, D., Sorlí, J. v., Ros, E., Fiol, M., Estruch, R., Santos-Lozano, J. M., Arós, F., Serra-Majem, L., Pintó, X., Gómez-Gracia, E., & Muñoz-Bravo, C. (2022). Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study. Journal of Clinical Medicine, 11(22), 6664. 10.3390/jcm11226664 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21362 http://hdl.handle.net/20.500.13003/18678 36431140 L640101081 2-s2.0-85142627093 http://hdl.handle.net/20.500.12105/18851 887369700001 PREDIMED Cardiovascular disease Mediterranean diet Older populations Serum selenium Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study