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oai:repisalud.isciii.es:20.500.12105/188492024-02-27T15:24:32Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Mena-Vázquez, Natalia author Lisbona-Montañez, Jose Manuel author Redondo-Rodriguez, Rocío author Mucientes, Arkaitz author Manrique-Arija, Sara author Rioja, José author Garcia-Studer, Aimara author Ortiz-Márquez, Fernando author Cano-García, Laura author Fernández-Nebro, Antonio author 2022-11-08 To describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden. We performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid arthritis (RA) and 110 age- and sex-matched controls. The main variable was cumulative inflammatory activity according to the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). High activity was defined as DAS28 ≥ 3.2 and low activity as DAS28 A total of 22/110 patients (20%) met the criteria for LORA (≥ 60 years). Patients with LORA more frequently had comorbid conditions than patients with YORA and controls. Compared with YORA patients, more LORA patients had cumulative high inflammatory activity from onset [13 (59%) vs. 28 (31%); p = 0.018] and high values for CRP (p = 0.039) and IL-6 (p = 0.045). Cumulative high inflammatory activity in patients with RA was associated with LORA [OR (95% CI) 4.69 (1.49-10.71); p = 0.008], smoking [OR (95% CI) 2.07 (1.13-3.78); p = 0.017], anti-citrullinated peptide antibody [OR (95% CI) 3.24 (1.15-9.13); p = 0.025], average Health Assessment Questionnaire (HAQ) score [OR (95% CI) 2.09 (1.03-14.23); p = 0.034], and physical activity [OR (95% CI) 0.99 (0.99-0.99); p = 0.010]. The second model revealed similar associations with inflammatory activity in patients with LORA. Control of inflammation after diagnosis is poorer and comorbidity more frequent in patients with LORA than in YORA patients and healthy controls. 10.3389/fmed.2022.1016159 2296-858X Frontiers in medicine http://hdl.handle.net/10668/20613 36425102 http://hdl.handle.net/20.500.12105/18849 aging early rheumatoid arthritis inflammation late-onset rheumatoid arthritis young-onset rheumatoid arthritis Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study.