2026-07-23T17:12:31Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/188452024-09-21T18:43:40Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Gamez, Nazaret author Bravo-Alegria, Javiera author Huang, Yumeng author Perez-Urrutia, Nelson author Dongarwar, Deepa author Soto, Claudio author Morales, Rodrigo 2024-02-27T15:24:29Z 2024-02-27T15:24:29Z 2022-10-31 10.3390/cells11213442 2073-4409 Cells http://hdl.handle.net/10668/20938 36359840 http://hdl.handle.net/20.500.12105/18845 Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of Aβ seeds accelerates brain amyloidosis in both susceptible experimental animals and humans. The mechanisms and elements governing the transport of misfolded Aβ from the periphery to the brain are not fully understood, although circulation and retrograde axonal transport have been proposed. Here, we demonstrate that injection of Aβ seeds in the tongue, a highly innervated organ, substantially accelerates the appearance of plaques in Tg2576 mice. In addition, the extra-nasal exposure of Aβ aggregates increased amyloid pathology in the olfactory bulb. Our results show that exposing highly innervated tissues to Aβ seeds accelerates AD-like pathological features, and suggest that Aβ seeds can be transported from peripheral compartments to the brain by retrograde axonal transport. Research in this direction may be relevant on different fronts, including disease mechanisms, diagnosis, and risk-evaluation of potential iatrogenic transmission of Aβ misfolding. eng Alzheimer’s disease amyloid-beta nasal cavity prion tongue Altering Brain Amyloidosis by Intra-Lingual and Extra-Nasal Exposure of Aβ Aggregates. research article