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oai:repisalud.isciii.es:20.500.12105/188442024-09-21T19:22:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Mucientes, Arkaitz author Lisbona, Jose Manuel author Mena-Vázquez, Natalia author Ruiz-Limón, Patricia author Manrique-Arija, Sara author Fernández-Nebro, Antonio 2024-02-27T15:24:29Z 2024-02-27T15:24:29Z 2022-10-27 10.3390/ijms232112989 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/21209 36361779 http://hdl.handle.net/20.500.12105/18844 This study aimed to evaluate the role of microRNAs (miRNA) as biomarkers of treatment response in rheumatoid arthritis (RA) patients through a systematic review of the literature. The MEDLINE and Embase databases were searched for studies including RA-diagnosed patients treated with disease-modifying antirheumatic drugs (DMARDs) that identify miRNAs as response predictors. Review inclusion criteria were met by 10 studies. The main outcome of the study was the response to treatment, defined according to EULAR criteria. A total of 839 RA patients and 67 healthy donors were included in the selected studies. RA patients presented seropositivity for the rheumatoid factor of 74.7% and anti-citrullinated C-peptide antibodies of 63.6%. After revision, 15 miRNAs were described as treatment response biomarkers for methotrexate, anti-tumour necrosis factor (TNF), and rituximab. Among treatments, methotrexate presented the highest number of predictor miRNAs: miR-16, miR-22, miR-132, miR-146a and miR-155. The most polyvalent miRNAs were miR-146a, predicting response to methotrexate and anti-TNF, and miR-125b, which predicts response to infliximab and rituximab. Our data support the role of miRNAs as biomarkers of treatment response in RA and point to DMARDs modifying the miRNAs expression. Nevertheless, further studies are needed since a meta-analysis that allows definitive conclusions is not possible due to the lack of studies in this field. eng biomarker disease-modifying antirheumatic drug microRNA rheumatoid arthritis systemic review treatment miRNA-Mediated Epigenetic Regulation of Treatment Response in RA Patients-A Systematic Review. research article