2026-05-21T23:03:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/188402024-09-21T18:27:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Espinosa Garcia, Elena
author
Arroyo Varela, Macarena
author
Larrosa Jimenez, Rafael
author
Gomez-Maldonado, Josefa
author
Cobo Dols, Manuel Angel
author
Claros, M Gonzalo
author
Bautista Moreno, Rocio
2024-02-27T15:24:25Z
2024-02-27T15:24:25Z
2022-10-13
10.1007/s12094-022-02969-7
1699-3055
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
http://hdl.handle.net/10668/21230
36229739
http://hdl.handle.net/20.500.12105/18840
Lung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis using liquid biopsies was expanded. A total of 30 samples of LC were analyzed to define potential miRNA biomarkers in liquid biopsies for LC. The biomarkers have been identified in interaction networks miRNA-mRNA. The potential biomarkers have been then validated in large cohorts. A total of 15 candidate miRNAs, that regulate the repression of 30 mRNAs, have been identified as a specific functional interaction network for squamous carcinoma, while the specific functional interaction network of adenocarcinoma consists of four candidate miRNAs that seem to handle the repression of five mRNA. Inspection of expression levels in larger cohorts validates the usefulness of the 11 candidates as biomarkers in liquid biopsies. The 11 candidate miRNAs found could be utilized to form diagnostic predictive biomarkers for LC in liquid biopsies.
eng
Biomarker
High-throughput sequencing
Lung cancer
RNA-seq
miRNA
Construction of miRNA-mRNA networks for the identification of lung cancer biomarkers in liquid biopsies.
research article