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oai:repisalud.isciii.es:20.500.12105/188392024-02-27T15:24:24Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16962col_20.500.12105_16975col_20.500.12105_16982

00925njm 22002777a 4500 dc González-Juanatey, Carlos author Anguita-Sánchez, Manuel author Barrios, Vivencio author Núñez-Gil, Iván author Gómez-Doblas, Juan José author García-Moll, Xavier author Lafuente-Gormaz, Carlos author Rollán-Gómez, María Jesús author Peral-Disdier, Vicente author Martínez-Dolz, Luis author Rodríguez-Santamarta, Miguel author Viñolas-Prat, Xavier author Soriano-Colomé, Toni author Muñoz-Aguilera, Roberto author Plaza, Ignacio author Curcio-Ruigómez, Alejandro author Orts-Soler, Ernesto author Segovia, Javier author Fanjul, Víctor author Cequier, Ángel author Savana Research Group, author 2022-10-11 Patients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. Unstructured data from the Electronic Health Records were extracted by EHRead®, a technology based on Natural Language Processing and machine learning. The association between new MACE and the variables of interest were investigated by univariable and multivariable analyses. From a source population of 2,184,662 patients, we identified 4072 adults diagnosed with T2DM and CAD (62.2% male, mean age 70 ± 11). The main comorbidities observed included arterial hypertension, hyperlipidemia, and obesity, with metformin and statins being the treatments most frequently prescribed. MACE development was associated with multivessel (Hazard Ratio (HR) = 2.49) and single coronary vessel disease (HR = 1.71), transient ischemic attack (HR = 2.01), heart failure (HR = 1.32), insulin treatment (HR = 1.40), and percutaneous coronary intervention (PCI) (HR = 2.27), whilst statins (HR = 0.73) were associated with a lower risk of MACE occurrence. In conclusion, we found six risk factors associated with the development of MACE which were related with cardiovascular diseases and T2DM severity, and treatment with statins was identified as a protective factor for new MACE in this study. 10.3390/jcm11206004 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21357 36294325 http://hdl.handle.net/20.500.12105/18839 MACE coronary artery disease diabetes mellitus electronic health records natural language processing risk factors Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing.