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00925njm 22002777a 4500 dc Rubín-García, María author Vitelli-Storelli, Facundo author Álvarez-Álvarez, Laura author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Hernáez, Álvaro author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Serra-Majem, Luís I author Cano-Ibañez, Naomi author Tur, Josep A author Marcos-Delgado, Alba author Tresserra-Rimbau, Anna author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emili author Vázquez-Ruiz, Zenaida author Babio, Nancy author Barragán, Rocío author Castañer-Niño, Olga author Razquin, Cristina author Tojal-Sierra, Lucas author Gómez-Gracia, Enrique author González-Palacios, Sandra author Morey, Marga author García-Rios, Antonio author Castro-Barquero, Sara author Bernal-López, María Rosa author Santos-Lozano, José Manuel author Ruiz-Canela, Miguel author Castro-Salomó, Antoni author Pascual-Castelló, Eva Cristina author Moldon, Verónica author Bullón-Vela, Vanessa author Sorto-Sanchez, Carolina author Cenoz-Osinaga, Juan Carlos author Gutiérrez, Liliana author Mengual, Maira author Lamuela-Raventós, Rosa María author Martín-Sánchez, Vicente author PREDIMED‐Plus Trial Investigators author 2022-10-07 Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research. Rubén-García M, Vitelli-Storelli F, Álvarez-Álvarez L, Martínez-González M, Salas-Salvado J, Corella D, et al. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. J Am Heart Assoc. 2022 Oct 18;11(20). 10.1161/JAHA.122.026053 2047-9980 Journal of the American Heart Association http://hdl.handle.net/10668/20201 http://hdl.handle.net/20.500.13003/18466 36205262 L2018262511 2-s2.0-85140129651 http://hdl.handle.net/20.500.12105/18836 869713100017 Hyperuricemia Polyphenols Uric acid Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk