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00925njm 22002777a 4500 dc Konieczna, Jadwiga author Fiol, Miguel author Colom, Antoni author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Soria-Florido, María Trinidad author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author López-Miranda, José author Estruch, Ramon author Bernal-López, M Rosa author Lapetra, José author Serra-Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín Sánchez, Vicente author Pintó, Xavier author Gaforio, José J author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Pascual, María author Sorlí, Jose V author Goday, Albert author Zulet, María Ángeles author Moreno-Rodriguez, Anai author Carmona González, Francisco Jesús author Valls-Enguix, Rafael author Janer, Juana M author Garcia-Rios, Antonio author Casas, Rosa author Gomez-Perez, Ana M author Santos-Lozano, José Manuel author Basterra-Gortari, F Javier author Martínez, María Ángeles author Ortega-Azorin, Carolina author Bayó, Joan author Abete, Itziar author Salaverria-Lete, Itziar author Ruiz-Canela, Miguel author Babio, Nancy author Carres, Lourdes author Romaguera, Dora author 2022-10-05 Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (β 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS. Konieczna J, Fiol M, Colom A, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome. Nutrients. 2022 Oct 5;14(19):4142. 10.3390/nu14194142 2072-6643 Nutrients http://hdl.handle.net/10668/21509 http://hdl.handle.net/20.500.13003/18474 36235794 L2019544931 2-s2.0-85139838456 http://hdl.handle.net/20.500.12105/18835 867238800001 Fatty liver index Hepatic steatosis index Liver health markers Metabolic syndrome Ultra-processed foods Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome