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00925njm 22002777a 4500 dc Valle-Hita, Cristina author Becerra-Tomás, Nerea author Díaz-López, Andrés author Vázquez-Ruiz, Zenaida author Megías, Isabel author Corella, Dolores author Goday, Albert author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín-Sánchez, Vicente author Pintó, Xavier author Gaforio, José J author Matía-Martín, Pilar author Vidal, Josep author Amengual-Galbarte, Angela author Daimiel, Lidia author Ros, Emilio author García-Arellano, Ana author Barragán, Rocío author Fitó, Montse author Peña-Orihuela, Patricia J author Asencio-Aznar, Alberto author Gómez-Gracia, Enrique author Martinez-Urbistondo, Diego author Morey, Marga author Casas, Rosa author Garrido-Garrido, Eva María author Tojal-Sierra, Lucas author Damas-Fuentes, Miguel author Goñi, Estibaliz author Ortega-Azorín, Carolina author Castañer, Olga author Garcia-Rios, Antonio author Gisbert-Sellés, Cristina author Sayón-Orea, Carmen author Schröder, Helmut author Salas-Salvadó, Jordi author Babio, Nancy author 2022-09-30 Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Valle-Hita C, Becerra-Tomás N, Díaz-López A, Vázquez-Ruiz Z, Megías I, Corella D, et al. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome. Front Nutr. 2022 Sep 30;9. 10.3389/fnut.2022.986190 2296-861X Frontiers in nutrition http://hdl.handle.net/10668/20676 http://hdl.handle.net/20.500.13003/18468 36245494 2-s2.0-85139911582 http://hdl.handle.net/20.500.12105/18829 869410000001 Albuminuria Chronic kidney disease (CKD) Dietary acid load Glomerular filtration rate (GFR) Kidney function Net endogenous acid production (NEAP) Potential renal acid load (PRAL) Renal nutrition Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome