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Repisalud author Marhuenda-Muñoz, María author Domínguez-López, Inés author Langohr, Klaus author Tresserra-Rimbau, Anna author Martínez González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Zomeño, María Dolores author Martínez, J Alfredo author Alonso-Gómez, Angel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramón author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Ll author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín-Sánchez, Vicente author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Toledo, Estefanía author Fernández de la Puente Cervera, María author Barragán, Rocío author Fitó, Montse author Tojal-Sierra, Lucas author Gómez-Gracia, Enrique author Zazo, Juan Manuel author Morey, Marga author García-Ríos, Antonio author Casas, Rosa author Gómez-Pérez, Ana M author Santos-Lozano, José Manuel author Vázquez-Ruiz, Zenaida author Atzeni, Alessandro author Asensio, Eva M author Gili-Riu, M Mar author Bullon, Vanessa author Moreno-Rodriguez, Anai author Lecea, Oscar author Babio, Nancy author Peñas Lopez, Francesca author Gómez Melis, Guadalupe author Lamuela-Raventós, Rosa M 2024-02-27T15:24:05Z 2024-02-27T15:24:05Z 2022-09-29 Marhuenda-Muñoz M, Domínguez-López I, Langohr K, Tresserra-Rimbau A, Martínez González MÁ, Salas-Salvadó J, et al. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk. Front Nutr. 2022 Sep 29;9. 10.3389/fnut.2022.967967 2296-861X Frontiers in nutrition http://hdl.handle.net/10668/20672http://hdl.handle.net/20.500.13003/18300 36245542 2-s2.0-85140035283 http://hdl.handle.net/20.500.12105/18826 868194600001 Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. eng Mediterranean diet PREDIMED-plus study cardiovascular health liquid chromatography mass spectrometry plasma carotenoids Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk research article