2026-04-29T17:03:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/188192024-09-21T20:11:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
García-Caballero, Melissa
author
Sokol, Liliana
author
Cuypers, Anne
author
Carmeliet, Peter
2024-02-27T15:23:59Z
2024-02-27T15:23:59Z
2022-09-21
10.3390/ijms231911052
1422-0067
International journal of molecular sciences
http://hdl.handle.net/10668/21199
36232355
http://hdl.handle.net/20.500.12105/18819
The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer.
eng
metabolic reprogramming
tumor angiogenesis
tumor endothelial cell metabolism
tumor microenvironment
Metabolic Reprogramming in Tumor Endothelial Cells.
research article