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00925njm 22002777a 4500 dc García-Caballero, Melissa author Sokol, Liliana author Cuypers, Anne author Carmeliet, Peter author 2022-09-21 The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer. 10.3390/ijms231911052 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/21199 36232355 http://hdl.handle.net/20.500.12105/18819 metabolic reprogramming tumor angiogenesis tumor endothelial cell metabolism tumor microenvironment Metabolic Reprogramming in Tumor Endothelial Cells.