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00925njm 22002777a 4500 dc Valle-Hita, Cristina author Díaz-López, Andrés author Becerra-Tomás, Nerea author Martínez-González, Miguel A author García, Verónica Ruiz author Corella, Dolores author Goday, Albert author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Luís author Cano-Ibáñez, Naomi author Tur, Josep A author Rubín-García, María author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Fontao, Sebastian Mas author Daimiel, Lidia author Ros, Emilio author Toledo, Estefania author Sorlí, José V author Roca, C author Abete, Iztiar author Moreno-Rodriguez, Anai author Crespo-Oliva, Edelys author Candela-García, Inmaculada author Morey, Marga author Garcia-Rios, Antonio author Casas, Rosa author Fernández-García, José Carlos author Santos-Lozano, José Manuel author Diez-Espino, Javier author Ortega-Azorín, Carolina author Comas, M author Zulet, M Angeles author Sorto-Sanchez, Carolina author Ruiz-Canela, Miguel author Fitó, Montse author Salas-Salvadó, Jordi author Babio, Nancy author 2022-04-02 Purpose: To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods: We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Valle-Hita C, Diaz-Lopez A, Becerra-Tomas N, Martinez-Gonzalez MA, Garcia VR, Corella D, et al. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk. Eur J Nutr. 2022 Sep;61(6):3095-108. Epub 2022 Apr 2. 10.1007/s00394-022-02838-7 1436-6215 European journal of nutrition http://hdl.handle.net/10668/19908 https://hdl.handle.net/20.500.13003/19774 35366708 L2015498300 2-s2.0-85127591831 http://hdl.handle.net/20.500.12105/18804 777379000002 DASH diet Dietary patterns Glomerular filtration rate Kidney function Mediterranean diet Protein diet score Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk