2026-08-29T14:05:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/187992024-09-27T11:43:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16938col_20.500.12105_16927
Repisalud
author
Cattrini, Carlo
author
Caffo, Orazio
author
De Giorgi, Ugo
author
Mennitto, Alessia
author
Gennari, Alessandra
author
Olmos, David
author
Castro, Elena
2024-02-27T15:16:17Z
2024-02-27T15:16:17Z
2022-03-31
10.3390/cancers14071792
2072-6694
Cancers
http://hdl.handle.net/10668/20884
35406564
http://hdl.handle.net/20.500.12105/18799
Nonmetastatic castration-resistant prostate cancer (nmCRPC) represents a condition in which patients with prostate cancer show biochemical progression during treatment with androgen-deprivation therapy (ADT) without signs of radiographic progression according to conventional imaging. The SPARTAN, ARAMIS and PROSPER trials showed that apalutamide, darolutamide and enzalutamide, respectively, prolong metastasis-free survival (MFS) and overall survival (OS) of nmCRPC patients with a short PSA doubling time, and these antiandrogens have been recently introduced in clinical practice as a new standard of care. No direct comparison of these three agents has been conducted to support treatment choice. In addition, a significant proportion of nmCRPC on conventional imaging is classified as metastatic with new imaging modalities such as the prostate-specific membrane antigen positron emission tomography (PSMA-PET). Some experts posit that these "new metastatic" patients should be treated as mCRPC, resizing the impact of nmCRPC trials, whereas other authors suggest that they should be treated as nmCRPC patients, based on the design of pivotal trials. This review discusses the most convincing evidence regarding the use of novel antiandrogens in patients with nmCRPC and the implications of novel imaging techniques for treatment selection.
eng
PSMA-PET
androgen-receptor signaling inhibitors
apalutamide
conventional imaging
darolutamide
enzalutamide
nmCRPC
nonmetastatic castration-resistant prostate cancer
Apalutamide, Darolutamide and Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC): A Critical Review.
research article