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00925njm 22002777a 4500 dc Ramos-Rincon, Jose-Manuel author Cobos-Palacios, Lidia author López-Sampalo, Almudena author Ricci, Michele author Rubio-Rivas, Manuel author Martos-Pérez, Francisco author Lalueza-Blanco, Antonio author Moragón-Ledesma, Sergio author Fonseca-Aizpuru, Eva-María author García-García, Gema-María author Beato-Perez, Jose-Luis author Josa-Laorden, Claudia author Arnalich-Fernández, Francisco author Molinos-Castro, Sonia author Torres-Peña, José-David author Vargas-Núñez, Juan-Antonio author Mendez-Bailon, Manuel author Loureiro-Amigo, Jose author Hernández-Garrido, María-Soledad author Peris-García, Jorge author López-Reboiro, Manuel-Lorenzo author Barón-Franco, Bosco author Casas-Rojo, Jose-Manuel author Gómez-Huelgas, Ricardo author On Behalf Of The Semi-Covid-Network, author 2022-03-31 Background: This work aims to analyze clinical outcomes according to ethnic groups in patients hospitalized for COVID-19 in Spain. Methods: This nationwide, retrospective, multicenter, observational study analyzed hospitalized patients with confirmed COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry) from 1 March 2020 to 31 December 2021. Clinical outcomes were assessed according to ethnicity (Latin Americans, Sub-Saharan Africans, Asians, North Africans, Europeans). The outcomes were in-hospital mortality (IHM), intensive care unit (ICU) admission, and the use of invasive mechanical ventilation (IMV). Associations between ethnic groups and clinical outcomes adjusted for patient characteristics and baseline Charlson Comorbidity Index values and wave were evaluated using logistic regression. Results: Of 23,953 patients (median age 69.5 years, 42.9% women), 7.0% were Latin American, 1.2% were North African, 0.5% were Asian, 0.5% were Sub-Saharan African, and 89.7% were European. Ethnic minority patients were significantly younger than European patients (median (IQR) age 49.1 (40.5−58.9) to 57.1 (44.1−67.1) vs. 71.5 (59.5−81.4) years, p < 0.001). The unadjusted IHM was higher in European (21.6%) versus North African (11.4%), Asian (10.9%), Latin American (7.1%), and Sub-Saharan African (3.2%) patients. After further adjustment, the IHM was lower in Sub-Saharan African (OR 0.28 (0.10−0.79), p = 0.017) versus European patients, while ICU admission rates were higher in Latin American and North African versus European patients (OR (95%CI) 1.37 (1.17−1.60), p < 0.001) and (OR (95%CI) 1.74 (1.26−2.41), p < 0.001). Moreover, Latin American patients were 39% more likely than European patients to use IMV (OR (95%CI) 1.43 (1.21−1.71), p < 0.001). Conclusion: The adjusted IHM was similar in all groups except for Sub-Saharan Africans, who had lower IHM. Latin American patients were admitted to the ICU and required IMV more often. 10.3390/jcm11071949 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21262 35407557 http://hdl.handle.net/20.500.12105/18798 COVID-19 SARS-CoV-2 Spain ethnic groups migrants minority groups Ethnicity and Clinical Outcomes in Patients Hospitalized for COVID-19 in Spain: Results from the Multicenter SEMI-COVID-19 Registry.