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oai:repisalud.isciii.es:20.500.12105/187942024-10-03T12:51:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16967

00925njm 22002777a 4500 dc Romero-Godoy, Rosalinda author Romero-Godoy, Sara Raquel author Romero-Acebal, Manuel author Gutiérrez-Bedmar, Mario author 2022-03-29 Chronic tension-type headache (CTTH) is a common disease with no fully defined pathophysiological processes. We designed a study to value electrophysiological responses in these patients and their correlation with possible psychopathological manifestations in order to deepen understanding of central and peripheral mechanisms of CTTH. In 40 patients with CTTH and 40 healthy controls, we used electrical stimulation to determine sensory threshold (SPT) and pain perception threshold (PPT) and the characteristics of the electrophysiological sensory nerve action potential (SNAP): initial sensory response (ISR) and supramaximal response (SMR). We then calculated the intensity differences between thresholds (IDT), namely SPT-PPT, ISR-SMR and SMR-PPT, and correlated these IDTs with psychological characteristics: trait and state anxiety, depression, and emotional regulation. The SPT, together with the ISR and SMR thresholds, were higher (p < 0.01) in CTTH patients. The SMR-PPT IDT was smaller and correlated with significantly higher indicators of depression, state and trait anxiety, and poorer cognitive reappraisal. CTTH patients have less capacity to recognize non-nociceptive sensory stimuli, greater tendency toward pain facilitation, and a poor central pain control requiring higher stimulation intensity thresholds to reach the start and the peak amplitude of the SNAP. This is consistent with relative hypoexcitability of the Aβ nerve fibers in distant regions from the site of pain, and therefore, it could be considered a generalized dysfunction with a focal expression. Pain facilitation is directly associated with psychological comorbidity. Romero-Godoy R, Romero-Godoy SR, Romero-Acebal M, Gutierrez-Bedmar M. Sensory Thresholds and Peripheral Nerve Responses in Chronic Tension-Type Headache and Neuropsychological Correlation. J Clin Med. 2022 Apr;11(7):1905. 10.3390/jcm11071905 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21261 https://hdl.handle.net/20.500.13003/19813 35407512 L2016116257 2-s2.0-85127441231 http://hdl.handle.net/20.500.12105/18794 780609500001 Aβ fiber excitability Central sensitization Chronic tension-type headache Electrical nerve stimulation Pain threshold Peripheral sensitization Sensory threshold Sensory Thresholds and Peripheral Nerve Responses in Chronic Tension-Type Headache and Neuropsychological Correlation