2026-04-29T04:09:12Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187912024-09-22T00:12:20Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Palmquist-Gomes, Paul author Marín-Sedeño, Ernesto author Ruiz-Villalba, Adrián author Rico-Llanos, Gustavo Adolfo author Pérez-Pomares, José María author Guadix, Juan Antonio 2024-02-27T15:16:11Z 2024-02-27T15:16:11Z 2022-03-25 http://hdl.handle.net/10668/21145 http://hdl.handle.net/20.500.12105/18791 35408974 10.3390/ijms23073614 1422-0067 International journal of molecular sciences The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli. eng avian embryo cardiac regeneration cartilage chondrocytes differentiation epicardial-derived cells epicardium proepicardium quail to chick chimeras In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells. research article