2026-05-20T04:01:52Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187902024-09-21T20:25:32Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16990
Repisalud author Chiva-Blanch, Gemma author Giró, Oriol author Cofán, Montserrat author Calle-Pascual, Alfonso L author Delgado, Elías author Gomis, Ramon author Jiménez, Amanda author Franch-Nadal, Josep author Rojo Martínez, Gemma author Ortega, Emilio 2024-02-27T15:16:10Z 2024-02-27T15:16:10Z 2022-03-25 10.3390/nu14071368 2072-6643 Nutrients http://hdl.handle.net/10668/21465 35405981 http://hdl.handle.net/20.500.12105/18790 The identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), α-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes. eng alpha-linolenic acid fatty acids linoleic acid omega-3 fatty acids type 2 diabetes worse of glucose metabolism Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. research article