2026-04-29T06:45:18Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/187842024-02-27T15:16:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Aguilar-Castillo, María José author Cabezudo-García, Pablo author Ciano-Petersen, Nicolas Lundahl author García-Martin, Guillermina author Marín-Gracia, Marta author Estivill-Torrús, Guillermo author Serrano-Castro, Pedro Jesús author 2022-03-19 Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources, it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. For this reason, we performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways involved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drugs. 2227-9059 http://hdl.handle.net/10668/20824 http://hdl.handle.net/20.500.12105/18784 35327518 10.3390/biomedicines10030716 Biomedicines epilepsy epileptogenesis neuroimmunology neuroinflammation treatment Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies.