2026-06-14T05:07:07Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187732024-09-21T18:28:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Rodríguez-Pérez, María Dolores author Pérez de Algaba, Inmaculada author Martín-Aurioles, Esther author Arrebola, María Monsalud author Ortega-Hombrados, Laura author Verdugo, Cristina author Fernández-Prior, María África author Bermúdez-Oria, Alejandra author De La Cruz, José Pedro author González-Correa, José Antonio 2024-02-27T15:15:57Z 2024-02-27T15:15:57Z 2022-03-08 10.3390/nu14061146 2072-6643 Nutrients http://hdl.handle.net/10668/21459 35334801 http://hdl.handle.net/20.500.12105/18773 The aim of this study was to assess the possible neuroprotective effect of 3',4'-dihydroxyphenylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect is modified by the presence of another EVOO polyphenol, hydroxytyrosol (HT). The neuroprotective effect was assessed in a hypoxia-reoxygenation model in brain slices and by quantifying retinal nerve cells. The animals were distributed as follows: (1) normoglycemic rats (NDR), (2) diabetic rats (DR), (3) DR treated with HT (5 mg/kg/day p.o.), (4) DR treated with DHPG (0.5 mg/kg/day), or (5) with 1 mg/kg/day, (6) DR treated with HT plus DHPG 0.5 mg/kg/day, or (7) HT plus 1 mg/kg/day p.o. DHPG. Diabetic animals presented higher levels of oxidative stress variables and lower numbers of neuronal cells in retinal tissue. The administration of DHPG or HT reduced most of the oxidative stress variables and brain lactate dehydrogenase efflux (LDH) as an indirect index of cellular death and also reduced the loss of retinal cells. The association of DHPG+HT in the same proportions, as found in EVOO, improved the neuroprotective and antioxidant effects of both polyphenols. eng 3′,4′-dihydroxyphenylglycol diabetes mellitus diabetic neuropathy extra virgin olive oil hydroxytyrosol Neuroprotective Effect of 3',4'-Dihydroxyphenylglycol in Type-1-like Diabetic Rats-Influence of the Hydroxytyrosol/3',4'-dihydroxyphenylglycol Ratio. research article