2026-08-13T07:15:25Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/187722024-09-21T18:30:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16959

00925njm 22002777a 4500 dc Serrano-Castro, Pedro J author Garzón-Maldonado, Francisco J author Casado-Naranjo, Ignacio author Ollero-Ortiz, Angela author Mínguez-Castellanos, Adolfo author Iglesias-Espinosa, Mar author Baena-Palomino, Pablo author Sánchez-Sanchez, Violeta author Sánchez-Pérez, Rosa María author Rubi-Callejon, José author Estévez-María, José Carlos author Galeano-Bilbao, Benito author Romero-Imbroda, Jesús author Sobrino, Beatriz author Arrabal-Gomez, Carlos author Oliver-Martos, Begoña author Muñoz-Becerra, Luis author Requena, Nerea author González Álvarez de Sotomayor, María Del Mar author Estivill-Torrus, Guillermo author Suarez, Juan author Ciano-Petersen, Nicolas Lundahl author Pons-Pons, Gracia author Reyes-Bueno, Jose Antonio author Cabezudo-Garcia, Pablo author Aguilar-Castillo, Maria José author De la Cruz Cosme, Carlos author Duque-Holguera, María author Cuartero-Rodriguez, Eva author Vilches-Carrillo, Rosa María author Carrera-Muñoz, Ismael author Carnero-Pardo, Cristóbal author Ramirez-Garcia, Teresa author Oropesa, Juan Manuel author Dominguez-Mayoral, Ana author Pelaez-Viñas, Nazaret author Valiente, Lucia author de Fonseca, Fernando Rodríguez author 2022-03-03 Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases. 10.1038/s41598-022-07559-9 2045-2322 Scientific reports http://hdl.handle.net/10668/19593 35241761 http://hdl.handle.net/20.500.12105/18772 The cognitive and psychiatric subacute impairment in severe Covid-19.