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oai:repisalud.isciii.es:20.500.12105/187562024-09-21T21:49:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Damas-Fuentes, Miguel author Boughanem, Hatim author Molina-Vega, María author Tinahones, Francisco J author Fernández-García, José Carlos author Macías-González, Manuel author 2022-09-02 Vitamin D and testosterone deficiency have been widely related to obesity. However, only a few studies have investigated the effect of vitamin D on testosterone in the context of obesity, in which controversial results have been raised. The purpose of this study was to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and testosterone levels in young men with different grade of obesity. This cross-sectional study included 269 healthy young men with obesity (body mass index (BMI) ≥ 30 kg/m2). Participants were divided into two groups based on their serum 25(OH)D levels (134 subjects with vitamin D sufficiency and 135 participants with vitamin D deficiency, according to the 50th percentile of 25(OH)D). Serum 25(OH)D and sex hormones have been measured. The relationships between 25(OH)D, sex hormones, and obesity grades were investigated with linear and binary logistic regression analyses, as well as mediation analysis. Compared to the 25(OH)D sufficiency group, total and free testosterone levels were found to be decreased, whereas serum androstenedione levels were increased in the 25(OH)D deficiency group (p Serum 25(OH)D is associated with total testosterone levels in only those subjects with morbid obesity, suggesting a specific benefit in severe cases of obesity. Additional research is needed to elucidate possible common mechanisms. 10.3389/fendo.2022.960222 1664-2392 Frontiers in endocrinology http://hdl.handle.net/10668/20568 36120442 http://hdl.handle.net/20.500.12105/18756 morbid obesity obesity sex-related hormone total testosterone vitamin D 25-hydroxyvitamin D and testosterone levels association through body mass index: A cross-sectional study of young men with obesity.