2026-04-29T06:16:13Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/187462024-09-21T22:16:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Martínez-Esteban, María Dolores author Vázquez-Sánchez, Teresa author Pozo-Álvarez, Rafael author Moreno-Ortiz, Alicia author Alonso-Titos, Juana author Martín-Reyes, Guillermo author Ruiz-Esteban, Pedro author Gaitán-Román, Daniel author Hernández, Domingo author 2022-08-23 The association between cardiac complications, such as heart failure (HF), and chronic kidney disease (CKD) is well known. In this study, we examined the effectiveness and safety of treatment with neprilysin inhibition in patients with advanced chronic kidney disease (stage 3b-4). This single-centre, longitudinal, retrospective study of 31 months duration involved consecutive patients with CKD and HF with a reduced ejection fraction (HFrEF) who started treatment with sacubitril/valsartan. Glomerular filtration rate (GFR), cardiovascular risk factors, proteinuria, potassium, echocardiographic parameters and admissions for heart failure were analysed. The study comprised 25 patients with a median age of 73.2 ± 5.9 years. The most frequent aetiology of heart failure was ischemic heart disease. The median GFR was 29.4 ± 8.3 ml/min/1.73 m2 and the left ventricular ejection fraction (LVEF) 36.4 ± 8.9%. The GFR improved after initiating the treatment (F = 3.396, p = 0.019), as did the LVEF at one year of follow-up (p = 0.018). The number of visits to the emergency department for heart failure was also reduced. No patients needed to start renal replacement therapy. This study shows that sacubitril/valsartan may play a beneficial role in patients who have advanced CKD and HFrEF, with a satisfactory safety profile. http://hdl.handle.net/10668/20272 http://hdl.handle.net/20.500.12105/18746 35999504 10.1186/s12882-022-02919-z 1471-2369 BMC nephrology Chronic kidney disease Glomerular filtration rate Heart failure Neprilysin inhibitor Reduced ejection fraction Cardio-renal benefits of sacubitril/valsartan in patients with advanced chronic kidney disease: experience in daily clinical practice.