2026-04-29T23:03:56Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187272025-05-08T08:42:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Navarro, Juan A author Decara, Juan author Medina-Vera, Dina author Tovar, Ruben author Lopez-Gambero, Antonio J author Suarez, Juan author Pavón, Francisco Javier author Serrano, Antonia author de Ceglia, Marialuisa author Sanjuan, Carlos author Baltasar, Yolanda Alfonso author Baixeras, Elena author Rodríguez de Fonseca, Fernando 2024-02-27T15:10:09Z 2024-02-27T15:10:09Z 2022-07-30 10.3390/pharmaceutics14081594 1999-4923 Pharmaceutics http://hdl.handle.net/10668/21557 36015220 http://hdl.handle.net/20.500.12105/18727 The widespread use of added sugars or non-nutritive sweeteners in processed foods is a challenge for addressing the therapeutics of obesity and diabetes. Both types of sweeteners generate health problems, and both are being blamed for multiple complications associated with these prevalent diseases. As an example, fructose is proven to contribute to obesity and liver steatosis, while non-nutritive sweeteners generate gut dysbiosis that complicates the metabolic control exerted by the liver. The present work explores an alternative approach for sweetening through the use of a simple carob-pod-derived syrup. This sweetener consists of a balanced mixture of fructose (47%) and glucose (45%), as sweetening sugars, and a functional natural ingredient (D-Pinitol) at a concentration (3%) capable of producing active metabolic effects. The administration of this syrup to healthy volunteers (50 g of total carbohydrates) resulted in less persistent glucose excursions, a lower insulin response to the hyperglycemia produced by its ingestion, and an enhanced glucagon/insulin ratio, compared to that observed after the ingestion of 50 g of glucose. Daily administration of the syrup to Wistar rats for 10 days lowered fat depots in the liver, reduced liver glycogen, promoted fat oxidation, and was devoid of toxic effects. In addition, this repeated administration of the syrup improved glucose handling after a glucose (2 g/kg) load. Overall, this alternative functional sweetener retains the natural palatability of a glucose/fructose syrup while displaying beneficial metabolic effects that might serve to protect against the progression towards complicated obesity, especially the development of liver steatosis. eng D-Pinitol Carob fruit Insulin Insulin resistance Liver steatosis Pituitary hormones Sweeteners Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes research article