2026-08-29T13:36:35Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187222024-02-27T15:10:06Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Leiva-Gea, Isabel author Fernández, Cristina Antúnez author Cardona-Hernandez, Roque author Lozano, Marta Ferrer author Bahíllo-Curieses, Pilar author Arroyo-Díez, Javier author León, María Clemente author Martín-Frías, Maria author Barreiro, Santiago Conde author Delgado, Andrés Mingorance author Sánchez, Jacobo Pérez author Diabetes Group of the Spanish Pediatric Endocrinology Society (SEEP) 2024-02-27T15:10:06Z 2024-02-27T15:10:06Z 2022-07-26 10.3390/jcm11154338 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/21326 35893428 http://hdl.handle.net/20.500.12105/18722 Objective: To assess the impact of the COVID-19 pandemic and lockdown measures on the presenting characteristics (age at diagnosis, severity, monthly distribution) of newly diagnosed type 1 diabetes in Spanish children. Research DesignandMethods: An ambispective observational multicenter study was conducted in nine Spanish tertiary-level hospitals between January 2015 and March 2021. Inclusion criteria: new cases of type 1 diabetes in children (0-14 years) recording age, sex, date of diagnosis, presence of diabetic ketoacidosis (DKA) at onset, and severity of DKA. Data were compared before and during the pandemic. Results: We registered 1444 new cases of type 1 diabetes in children: 1085 in the pre-pandemic period (2015-2019) and 359 during the pandemic (2020-March 2021). There was a significant increase in the group aged ≤4 years in the pandemic period (chi-squared = 10.986, df 2, p = 0.0041). In 2020-2021, cases of DKA increased significantly by 12% (95% CI: 7.2-20.4%), with a higher percentage of moderate and severe DKA, although this increase was not significant. In 2020, there was a sharp decrease in the number of cases in March, with a progressive increase from May through November, higher than in the same months of the period 2015-2019, highlighting the increase in the number of cases in June, September, and November. The first three months of 2021 showed a different trend to that observed both in the years 2015-2019 and in 2020, with a marked increase in the number of cases. Conclusions: A change in monthly distribution was described, with an increase in DKA at onset of type 1 diabetes. No differences were found in severity, although there were differences in the age distribution, with an increase in the number of cases in children under 4 years of age. eng COVID-19 DKA diabetes onset type 1 diabetes Increased Presentation of Diabetic Ketoacidosis and Changes in Age and Month of Type 1 Diabetes at Onset during the COVID-19 Pandemic in Spain. research article