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00925njm 22002777a 4500 dc Bouzas, Cristina author Bibiloni, Maria Del Mar author Garcia, Silvia author Mateos, David author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Goday, Albert author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author Lopez-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Lluís author Riquelme-Gallego, Blanca author Martín-Sánchez, Vicente author Pintó, Xavier author Gaforio, José J author Matía, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Pascual-Roquet-Jalmar, Elena author Babio, Nancy author Gonzalez-Monge, Inmaculada author Castañer, Olga author Abete, Itziar author Sorto-Sánchez, Carolina author Carlos Benavente-Marín, Juan author Torres-Collado, Laura author Martin, Marian author García-Ríos, Antonio author Castro-Barquero, Sara author Fernández-García, José Carlos author Santos-Lozano, José Manuel author Fernandez-Lazaro, Cesar I author Salas-Huetos, Albert author Guillem-Saiz, Patricia author Zomeño, María Dolores author Ángeles Zulet, Maria author Goikoetxea-Bahon, Amaia author Gea, Alfredo author Nishi, Stephanie K author Schröder, Helmut author Tur, Josep A author PREDIMED-Plus investigators author 2022-07-22 Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: ≥0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903); ≤-4.0 kg (T3, n = 1,958). A food frequency questionnaire assessed diet and the Minnesota-REGICOR questionnaire assessed physical activity. The Framingham equation assessed cardiovascular risks. The changes in the severity of MetS were also assessed. The Beck Depression Inventory assessed depressive symptoms and the SF-36 assessed health-related quality of life. Data were analyzed using general linear models. Results: BMI decreased at T2 and T3 (T1: 0.3, T2: -0.7, T3: -1.9). The most significant improvement in diet quality was observed at T3. Cardiovascular risk decreased at T2 and T3. Mean reductions in MetS severity score were: -0.02 at T1, -0.39 at T2 and -0.78 at T3. The perception of physical health increases in successive tertiles. Conclusions: In older adults with MetS, more ambitious desired weight loss goals were associated with improvements in diet, cardiovascular health and perceived physical health during the first year of a healthy lifestyle intervention programme. Weight dissatisfaction needs to be considered by health professionals. Clinical trial registration: http://www.isrctn.com/ISRCTN89898870, identifier 89898870. Bouzas C, Bibiloni MDM, Garcia S, Mateos D, Martínez-González MÁ, Salas-Salvadó J, et al. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up. Front Nutr. 2022;9:848055. 2296-861X http://hdl.handle.net/10668/20659 http://hdl.handle.net/20.500.13003/18104 http://hdl.handle.net/20.500.12105/18720 35938116 10.3389/fnut.2022.848055 Frontiers in nutrition 2-s2.0-85135518500 837409900001 Mediterranean diet PREDIMED-plus trial Desired weight loss Health perception Metabolic syndrome Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up