2026-04-29T00:59:56Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/187042024-02-27T15:09:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969col_20.500.12105_16980col_20.500.12105_16983col_20.500.12105_16990
Repisalud author García Clemente, Marta author Olveira, Casilda author Girón, Rosa author Máiz, Luis author Sibila, Oriol author Golpe, Rafael author Menéndez, Rosario author Rodríguez, Juan author Barreiro, Esther author Rodríguez Hermosa, Juan Luis author Prados, Concepción author De la Rosa, David author Carbajal, Claudia Madrid author Solís, Marta author Martínez-García, Miguel Ángel 2024-02-27T15:09:04Z 2024-02-27T15:09:04Z 2022-07-07 2077-0383 http://hdl.handle.net/10668/21320 http://hdl.handle.net/20.500.12105/18704 35887723 10.3390/jcm11143960 Journal of clinical medicine The objective of the study was to analyze the factors associated with chronic bronchial infection (CBI) due to methicillin-susceptible Staphylococcus aureus (SA) and assess the clinical impact on severity, exacerbations, hospitalizations, and loss of lung function compared to patients with no isolation of PPMs in a large longitudinal series of patients from the Spanish bronchiectasis registry (RIBRON). Material and methods: A prospective, longitudinal, multicenter study was conducted with patients included in the RIBRON registry between January 2015 and October 2020. The inclusion criteria were an age of 18 years or older and an initial diagnosis of bronchiectasis. Patients recorded in the registry had a situation of clinical stability in the absence of an exacerbation in the four weeks before their inclusion. All patients were encouraged to provide a sputum sample at each visit for microbiological culture. Annual pulmonary function tests were performed according to the national spirometry guidelines. Results: A total of 426 patients were ultimately included in the study: 77 patients (18%) with CBI due to SA and 349 (82%) who did not present any isolation of PPMs in sputum. The mean age was 66.9 years (16.2), and patients 297 (69.7%) were female, with an average BMI of 25.1 (4.7) kg/m2 and an average Charlson index of 1.74 (1.33). The mean baseline value of FEV1 2 L was 0.76, with a mean FEV1% of 78.8% (23.1). One hundred and seventy-two patients (40.4%) had airflow obstruction with FEV1/FVC eng Staphylococcus aureus bronchiectasis chronic bronchial infection Impact of Chronic Bronchial Infection by Staphylococcus aureus on Bronchiectasis. research article