2026-04-29T07:22:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/186902024-10-04T10:47:59Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16969col_20.500.12105_16977col_20.500.12105_16982col_20.500.12105_16983col_20.500.12105_16989
Repisalud
author
Martínez-Urbistondo, Diego
author
San Cristóbal, RodrigoSan
author
Villares, Paula
author
Martínez-González, Miguel Ángel
author
Babio, Nancy
author
Corella, Dolores
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Del Val, José Luis
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Ordovás, José M
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Alonso-Gómez, Ángel M
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Wärnberg, Julia
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Vioque, Jesús
author
Romaguera, Dora
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López-Miranda, José
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Estruch, Ramon
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Tinahones, Francisco J
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Lapetra, José
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Serra-Majem, J Luís
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Bueno-Cavanillas, Aurora
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Tur, Josep A
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Marcos, Alba
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Pintó, Xavier
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Delgado-Rodríguez, Miguel
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Matía-Martín, Pilar
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Vidal, Josep
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Vázquez, Clotilde
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Ros, Emilio
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Bullón Vela, María Vanessa
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Palau, Antoni
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Masagué, Marta
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Abete, Itziar
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Moreno-Rodríguez, Anai
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Candela-García, Inma
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Konieczna, Jadwiga
author
García-Ríos, Antonio
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Juárez, Oscar Lecea
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Martín, Paco
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Goday, Albert
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Zulet, M Ángeles
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Vaquero-Luna, Jessica
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Orea, María Del Carmen Sayón
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Megías, Isabel
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Baltasar, Enric
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Martínez, J Alfredo
author
Daimiel, Lidia
2024-02-27T15:08:51Z
2024-02-27T15:08:51Z
2022-06-29
Martínez-Urbistondo D, San Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, et al. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Front Endocrinol (Lausanne). 2022 Jun 29;13.
1664-2392
http://hdl.handle.net/10668/20564http://hdl.handle.net/20.500.13003/18128
http://hdl.handle.net/20.500.12105/18690
35846291
10.3389/fendo.2022.868795
Frontiers in endocrinology
2-s2.0-85134176497
835976900001
L2018233028
Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Results: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).
eng
HRQoL
NAFLD
Mediterranean diet
Metabolic syndrome
Physical activity
Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort
research article